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New Products: PacBio's SMRT Analysis

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Pacific Biosciences has released SMRT Analysis 1.3.3, a software upgrade that enables the detection of base modifications from sequencing data. Customers can now automatically detect common bacterial methylation, including N6-methyladenine, N4-methylcytosine, and Tet-converted 5-methylcytosine. The upgrade also enables methyltransferase recognition motif analysis and integrates the Celera assembler.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.