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New Products: PacBio's HGAp and Quiver; Bowtie


Pacific Biosciences has launched new assembly and base-calling tools, HGAp and Quiver, available for download on its DevNet site.

HGAp performs de novo assembly using data from the PacBio long insert library and achieves greater than 99.999 percent (Q50) finished accuracy. The tool requires just one long-insert library prep and uses single-pass reads for the assembly rather than circular consensus sequencing reads, which reduces the number of SMRT cells required by around 50 percent, according to the company.

Quiver is an algorithm for calling consensus from multiple PacBio subreads using a hidden Markov model and both the base calls and QV metrics to infer the sequence.

Johns Hopkins Bloomberg School of Public Health has released Bowtie version 2.0.4, available here, which fixed a command-line parsing issue and an issue on Windows, and includes updated scripts and documentation.

The Scan

And For Adolescents

The US Food and Drug Administration has authorized the Pfizer-BioNTech SARS-CoV-2 vaccine for children between the ages of 12 and 15 years old.

Also of Concern to WHO

The Wall Street Journal reports that the World Health Organization has classified the SARS-CoV-2 variant B.1.617 as a "variant of concern."

Test for Them All

The New York Times reports on the development of combined tests for SARS-CoV-2 and other viruses like influenza.

PNAS Papers on Oral Microbiome Evolution, Snake Toxins, Transcription Factor Binding

In PNAS this week: evolution of oral microbiomes among hominids, comparative genomic analysis of snake toxins, and more.