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New Products: NuGen's Ovation Fusion Panel

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NuGen has launched Ovation Fusion Panel Target Enrichment System, an assay that will detect all possible fusion events involving 446 cancer fusion genes. The assay uses NuGen's proprietary Single Primer Enrichment Technology, a single primer strategy that requires only one partner exon to be targeted, which enables detection of both known and novel fusion events, as well as alternative isoforms, according to the company. It requires 10 ng of total RNA from either fresh frozen or formalin-fixed paraffin-embedded tissue.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.