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New Products: IDT's NGS Panels; CeGaT's Skin Disease Test; Syapse Software


Integrated DNA Technologies has launched two next-gen sequencing-based disease panels.

The xGen Inherited Disease Panel was designed in collaboration with Emory Genetics Laboratory and targets all the exons of genes in the Human Gene Mutation Database. The xGen Pan-Cancer Panel is based on the findings of the Cancer Genome Atlas and targets coding regions in 127 genes implicated in 12 tumor types.

Both panels feature xGen Lockdown Probes, which are 120-mer oligonucleotides with a 5' biotin modification.

The Center for Genomics and Transcriptomics has launched 11 next-gen sequencing panels for the diagnosis of hereditary skin diseases. Sequencing is performed on Illumina's HiSeq 2500 and potentially pathogenic variants are validated with capillary sequencing. The panels range in size from 7 genes to 55 genes and can be ordered individually or in combination.

Syapse plans to make third-party commercial omics interpretation providers' content available to hospitals and laboratories through the Syapse platform to enable clinical interpretation, reporting, and decision support. It will also make public and open databases like ClinVar, COSMIC, PhenoDB, and OMIM accessible through its platform.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.