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New Products: Beckman Coulter's SPRIworks HT; Sage Science's BluePippin; Riken's sample prep

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Beckman Coulter has launched SPRIworks HT, a high-throughput fragment library prep kit for Illumina sequencing platforms. The system uses the company's solid phase reversible immobilization technology and requires only 15 minutes of hands-on time. Up to 96 samples can be prepared in three hours without size selection, or six hours with size selection.


Sage Science has launched BluePippin, an instrument that automates size selection and DNA retrieval for library construction. The BluePippin is an updated version of Sage's Pippin Prep system, but with an added pulse-field power supply, which allows larger fragments of DNA to be separated with high resolution and accuracy. It can automatically collect DNA fragments up to 50 kilobase pairs, according to the company.


Researchers at the Riken Omics Science Center have developed an automated sample-prep workflow for the HeliScope sequencer. The workflow uses a method developed by the Riken team known as cap analysis of gene expression, or CAGE, and reduces the sample-prep time for 96 CAGE cDNA libraries from 42 days to eight days.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.