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New Products: Aug 10, 2010

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Agilent Technologies has released a new version of its SureSelect Human All Exon Kit, which it developed together with the Wellcome Trust Sanger Institute (see article, this issue). The new kit covers about 50 megabases in total, 12 megabases more than the old kit. Protocols for the kit support Illumina end sequencing, paired-end sequencing, and indexing in addition to fragment library format, paired-end sequencing, and barcoding on the SOLiD system. Online customization of the new kit will be available in the near future, according to the company.


Sage Science has released its Pippin Prep DNA size selection system, which automates the collection of DNA fragments for next-generation sequencing library preparation. The system can replace manual gel purification techniques, and it uses a proprietary electrophoretic approach that extracts narrow size distributions from sheared genomic DNA and takes only one to two minutes per sample, the company said.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.