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Agilent Technologies said that it has added multiplexing capability to its SureSelect Target Enrichment System.

SureSelect can now support multiplexed DNA sequencing of 12 to 16 samples per lane, resulting in a 16-fold increase in throughput, Agilent said.

Kits are optimized for the Illumina Genome Analyzer and the Applied Biosystems SOLiD. The Illumina can sequence 12 samples per lane for a total of 96 samples per run, while SOLiD can sequence 16 samples per quadrant or octet, allowing up to 256 samples to be processed per run.

The company said that the first SureSelect products with multiplexing capabilities are custom kits designed with its online design tool. Kits range from 10 to 5,000 reactions per custom kit.

New kits that include predefined content will be available in multiplexing format later this year, Agilent said.


New England Biolabs has released the NEBNext DNA Sample Prep Master Mix Set 3, which has been validated for use with Applied Biosystems' SOLiD 3 system.

NEBNext reagents enable sample preparation for downstream applications such as sequencing, NE Biolabs said. Available as sets, master mixes, or modules, the reagents allow customization based on the sequencing platform being used.


SoftGenetics said that its NextGene software now offers a "merge" function that lets users elongate reads, utilizing paired-end reads, to facilitate alignment, indel detection, and assembly.

The new functionality takes advantage of paired-end information, along with the additional coverage from sequenced overlapping DNA fragments, to produce long reads spanning the entire library size with an extremely low error rate, the company said.


GenBank 176.0 is available via FTP from the National Center for Biotechnology Information.

The release contains approximately 112 billion base pairs and 116 million entries for non-WGS, non-CON sequences, and 163 billion base pairs and 57 million entries for WGS sequences.

Uncompressed, release 176.0 flatfiles require roughly 432 gigabytes for sequence only.


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Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

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