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RainDance Technologies has added methyl-seq and ultra-deep resequencing applications for its RDT 1000 sequence enrichment platform.

Methyl-seq enables the targeted amplification of bisulfite-converted DNA for the sequence-based detection of methylated DNA. Ultra-deep resequencing allows users to characterize rare variants in highly heterogeneous samples, such as those found in cancer tumors. Standard PCR approaches have been difficult to use for this application, according to the company, because of the loss of accurate DNA representation.

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