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New Products: Jan 20, 2009

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GE Healthcare has launched Illustra TriplePrep, a kit to isolate genomic DNA, RNA, and total denatured protein simultaneously from a single, undivided sample. The kit contains two spin columns and six buffers for use with mammalian cell culture or animal tissue, and the preparation takes one hour, according to the company. The isolated gDNA, total RNA, and total denatured proteins are suitable for a range of applications, including PCR, restriction enzyme digestion, sequencing, array CGH, RT-PCR, gene expression microarrays, SDS-PAGE, Western blotting, 2-D DIGE, and LCMS.


SoftGenetics has added a SNP and indel detection module for reads from the Roche/454 Genome Sequencer FLX to its NextGene software.

The new module addresses the homopolymer-based errors of the FLX system. It uses high coverage of reads "to statistically polish and correct the inherent system errors," according to the company. Also, NextGene's alignment tool permits base pair mismatches between the sample sequences and reference, allowing the software to accurately align reads with long indels and identify them as mutations. The SNP detection application for 454 data identifies SNPs by accurately aligning sample reads with a reference.

Interested parties may request a 30-day trial of the software, or arrange for a web-based demonstration using their own data at the company's web site.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.