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New Products: Sep 14, 2011

Sep 14, 2011
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The Wellcome Trust Sanger Institute has released version 55 of COSMIC, the Catalogue of Somatic Mutations in Cancer. The new version includes new curations of the tumor suppressor gene PRDM1, fusions of CRTC1/CRTC3-MAML2, and three new systematic screen publications. Additionally, a new release of the Cancer Gene Census raises the number of known cancer genes to 464. Recently added genes include SF3B1, ARID2, CCNE1, CDK12, FUBP1, XPO1, and MED12.

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Clinical Sequencing
Sequencing
Diagnostics
Wellcome Sanger Institute
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Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.