New Methods Enable Quantitative Sequencing of Formyl-C, Study of Biological Role | GenomeWeb

Scientists in the UK have developed a new method for reading a recently discovered cytosine modification, 5-formylcytosine, at single-base resolution.

The approach, called reduced bisulfite sequencing, or redBS-seq, provides an alternative to another method, fCAB-seq, that was published by researchers in the US last year.

Together, the methods enhance researchers' toolkit for studying epigenetic modifications, which also include cytosine methylation and hydroxymethylation, allowing them to elucidate their potential biological role in mammalian cells.

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