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National Center for Biotechnology Information, Illumina, PlasmidFactory, Sigma-Aldrich

The National Center for Biotechnology Information has released dbSNP Build 127, which includes new genome mapping information for six species: Homo sapiens, Bos taurus, Felis catus, Sus scrofa, Bos indicus, and Bison bison
NCBI has also released its annotation of the zebrafish genome assembly, build 2.1, as well as its annotation of the gray short-tailed opossum genome assembly, build 2.1.

Illumina has launched the HumanCNV370-Duo, a microarray co-developed with DeCode Genetics that is designed to target regions of the genome that show copy number variation. The HumanCNV370-Duo allows researchers to analyze two samples simultaneously and access content for detecting disease-relevant CNV regions, the company said.
The HumanCNV370-Duo combines the content found on the company’s HumanHap300-Duo with an additional 55,000 markers designed to target around 11,000 copy number variant regions. The content on the array will also be available on Illumina's Human 1M, a single-chip solution that will profile over one million diverse genetic variants.
"Preliminary data from this array demonstrate that we can identify numerous novel CNV regions that were notoriously difficult to define using previous technologies and can look for new disease-associated genes and markers," Jeffrey Gulcher, chief scientific officer of DeCode, said in a statement.

PlasmidFactory has released several new vectors, including pDG, pDM, pDP1rs to pDP6rs, and pDG without a heparin binding motif. The company said it produces the vectors in reproducible quality and that its service includes the complete characterization of the products by LAL test, BCA test, UV spectroscopy, restriction analysis, detection of RNA and bacterial chromosomal DNA using AGE, and partial sequencing.

Sigma-Aldrich has introduced its Mission siRNA druggable genome libraries for human and rat. The libraries are sub-divided into 17 gene family panels, which are available for sale individually or together.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.