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Natera, Amal Therapeutics to Monitor Treatment Response in Colorectal Cancer Patients

NEW YORK (GenomeWeb) – Natera and Swiss biotech Amal Therapeutics plan to partner on a clinical trial to test Natera's bespoke circulating tumor DNA assay, Signatera, to assess treatment response in late-stage colorectal cancer patients.

The prospective clinical trial will assess Amal's cancer vaccine, ATP128, in combination with a PD-1 inhibitor in patients with stage IV colorectal cancer. Study investigators will use Signatera to measure patients' treatment response.

The trial "demonstrates the continued adoption of Signatera for use as a potential surrogate endpoint in clinical trials to evaluate treatment response and predict outcomes across a wide range of solid tumors," Alexey Aleshin, Natera's oncology medical director, said in a statement.

Natera CEO Steve Chapman added that the company now has more than 30 clinical trials with pharmaceutical companies underway that use its Signatera assay.