NEW YORK – A trio of methods based on nanopore sequencing are enabling researchers to find open chromatin regions in eukaryotic genomes, along with certain methylation and nucleosome positioning patterns.
"We now have the prospect for multi-omics at the single-molecule level," said Georgi Marinov, a postdoc in William Greenleaf's lab at Stanford University, who developed one of the new methods, single-molecule long-read accessible chromatin mapping sequencing (SMAC-seq).