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mRNA-Seq, FinchLab

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Illumina has launched mRNA-Seq, a product for full-length cDNA sequencing on its Genome Analyzer. Researchers can use mRNA-Seq to generate a full-sequence from any poly-A tailed RNA, allowing them to discover and profile novel transcripts, novel isoforms, alternative splice sites, rare transcripts, and cSNPs. To support the large quantities of data generated using mRNA-Seq, Illumina said it plans to launch a data analysis software program called GenomeStudio in November.
 

 
Geospiza has released a new version of its FinchLab software, which includes additions for the analysis of next-generation sequencing. The software tracks a sample from experimental design to results, linking sample information to quality control data and analysis results. FinchLab offers preconfigured data analysis pipelines and an application programming interface that researchers can use to develop novel approaches to data analysis. The current release supports the tag profiling, resequencing, transcriptome, and ChIP-Seq analysis pipelines for the Illumina Genome Analyzer, and tag profiling and transcriptome analysis pipelines for the Applied Biosystems SOLiD system. It also contains improvements for Roche 454 workflows and many aspects of the lab management system. The next release, planned for November, will include additional analysis capabilities for SOLiD and 454.

The Scan

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.

Analysis of Endogenous Parvoviral Elements Found Within Animal Genomes

Researchers at PLOS Biology have examined the coevolution of endogenous parvoviral elements and animal genomes to gain insight into using the viruses as gene therapy vectors.

Saliva Testing Can Reveal Mosaic CNVs Important in Intellectual Disability

An Australian team has compared the yield of chromosomal microarray testing of both blood and saliva samples for syndromic intellectual disability in the European Journal of Human Genetics.

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.