Skip to main content
Premium Trial:

Request an Annual Quote

Microbial Fingerprints, Health Insights Gleaned From Individual Gut Microbiome Dynamics

NEW YORK – A new sequencing study suggests gut microbial communities are individualized and relatively stable over time, though the extent of that genetic stability varies somewhat with the microbial species considered.

Researchers from the Netherlands and Israel did metagenomic sequencing on fecal samples from 338 participants in a prospective Dutch population study cohort over four years, searching for stable species in each individuals' microbial fingerprint, as well as unstable species that were not constant over the time points considered. Their results suggested gut microbial communities remained quite constant within individuals, compared to the microbial diversity differences found from one individual to the next.

"[T]he gut microbiome showed a degree of long-term within-individual stability in both microbial abundance and microbial genome," co-senior and corresponding authors Jingyuan Fun and Alexandra Zhemakova, with the University of Groningen's department of genetics, and their colleagues wrote in a paper published in Cell on Friday, noting that "the genetic makeup of microbes shows individuality that can be used as a fingerprint to distinguish metagenomic samples belonging to the same individual."

Still, the team noted that microbiome stability was not uniform across bugs belonging to the gut communities. Instead, the available SNP, structural variant, and other genetic data hinted that a handful of unstable species — including bugs implicated in human health and disease processes — may be less genetically constant over time than other gut microbes.

"The stable and variable microbial compositional and genetic components we observe can have different implications: individually stable microbial components might be used to identify their host, whereas variable microbial components might be related to phenotypic changes of the host," the authors proposed.

By focusing on microbes that were relatively stable within individuals, the team was able to link metagenomic sequences from participants at baseline and after four years with roughly 85 percent accuracy. A "microbial fingerprinting" approach developed from the initial cohort showed 95 percent accuracy for linking samples taken a year apart from the same individuals when applied to longitudinal gut microbiome data for 43 individuals profiled for the Human Microbiome Project.

Such results "demonstrate a potential application of our method in distinguishing sample mix-ups," the authors suggested, "but also raise potential privacy concerns for subjects enrolled in human microbiome research projects."

When the investigators attempted to tie gut microbial features to blood plasma levels for nearly 1,200 targeted liquid chromatography- and mass spectrometry-profiled metabolites, meanwhile, they uncovered more than 450 significant associations involving dozens of metabolites and related microbial features or abundance.

A similar host phenotype analysis highlighted 169 microbial features and almost three-dozen associated host phenotypes — ranging from body mass index and blood pressure to depression. Their subsequent in silico mediation analyses suggested that plasma metabolites may serve as a bridge between microbes in an individual's gut and some health features.

"Altogether, our longitudinal microbial associations and mediation analyses on host phenotypes and plasma metabolites reveal functional insights and putative causality for the role of the gut microbiome in human health and disease onset," the authors concluded.

The Scan

Genetic Ancestry of South America's Indigenous Mapuche Traced

Researchers in Current Biology analyzed genome-wide data from more than five dozen Mapuche individuals to better understand their genetic history.

Study Finds Variants Linked to Diverticular Disease, Presents Polygenic Score

A new study in Cell Genomics reports on more than 150 genetic variants associated with risk of diverticular disease.

Mild, Severe Psoriasis Marked by Different Molecular Features, Spatial Transcriptomic Analysis Finds

A spatial transcriptomics paper in Science Immunology finds differences in cell and signaling pathway activity between mild and severe psoriasis.

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.