Maximum-Depth Sequencing Detects Extremely Rare Variants, Has Potential Clinical Applications | GenomeWeb

NEW YORK (GenomeWeb) – Researchers from New York University have developed a method for detecting very rare mutations in a population of cells using error-corrected sequencing.

The approach, called maximum-depth sequencing (MDS), adds barcode and adaptor sequences directly onto a short sequence of interest so it can be amplified and sequenced many times in parallel to produce a consensus sequence.

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