Dennis Lo's team at the Chinese University of Hong Kong, which pioneered a shotgun sequencing approach to noninvasively detect fetal aneuploidies from maternal plasma, has tested a new targeted sequencing approach to detect trisomy but has found it inferior to the previous method.

While a targeted approach could have the advantage of being higher throughput and less costly than shotgun sequencing, Lo told Clinical Sequencing News that for now, he plans to stick with the shotgun approach because the targeted approach is "less robust."

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Jul
14
Sponsored by
Agilent Technologies

This online seminar will outline a recent example of the use of molecular barcoding in combination with next-generation sequencing to detect somatic mosaicism in cancer patients.