Lo Team Finds Targeted, SNP-Based Approach for T21 Detection 'Less Robust' than Shotgun Sequencing | GenomeWeb

Dennis Lo's team at the Chinese University of Hong Kong, which pioneered a shotgun sequencing approach to noninvasively detect fetal aneuploidies from maternal plasma, has tested a new targeted sequencing approach to detect trisomy but has found it inferior to the previous method.

While a targeted approach could have the advantage of being higher throughput and less costly than shotgun sequencing, Lo told Clinical Sequencing News that for now, he plans to stick with the shotgun approach because the targeted approach is "less robust."

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