Skip to main content
Premium Trial:

Request an Annual Quote

Last Week's Sequencing-Related Papers of Note: May 6, 2014


Resequencing studies of nonmodel organisms using closely related reference genomes: optimal experimental designs and bioinformatics approaches for population genomics.
Nevado B, Ramos-Onsins SE, Perez-Enciso M.
Mol Ecol. 2014 Apr;23(7):1764-79.

Quantifying alternative splicing from paired-end RNA-sequencing data.
Rossell D, Stephan-Otto Attolini C, Kroiss M, Stöcker A.
Ann Appl Stat. 2014 Mar;8(1):309-330.

Towards error-free profiling of immune repertoires.
Shugay M, Britanova OV, Merzlyak EM, Turchaninova MA, et al.
Nat Methods. 2014 May 4. [Epub ahead of print]

Expanded genetic codes in next generation sequencing enable decontamination and mitochondrial enrichment.
McKernan KJ, Spangler J, Zhang L, Tadigotla V, et al.
PLoS One. 2014 May 2;9(5):e96492.

Reconstructing the DNA methylation maps of the Neandertal and the Denisovan.
Gokhman D, Lavi E, Prüfer K, Fraga MF, et al.
Science. 2014 May 2;344(6183):523-527.

ReadXplorer - visualization and analysis of mapped sequences.
Hilker R, Stadermann KB, Doppmeier D, Kalinowski J, et al.
Bioinformatics. 2014 Apr 30. [Epub ahead of print]

Impact of artifact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data.
Carroll TS, Liang Z, Salama R, Stark R, de Santiago I.
Front Genet. 2014 Apr 10;5:75.

Microfluidic single-cell whole-transcriptome sequencing.
Streets AM, Zhang X, Cao C, Pang Y, et al.
Proc Natl Acad Sci U S A. 2014 Apr 29. [Epub ahead of print]

A programmable method for massively parallel targeted sequencing.
Hopmans ES, Natsoulis G, Bell JM, Grimes SM, et al.
Nucleic Acids Res. 2014 Apr 29. [Epub ahead of print]

Transcript mapping based on dRNA-seq data.
Bischler T, Kopf M, Voß B.
BMC Bioinformatics. 2014 Apr 29;15(1):122.

RECLU: a pipeline to discover reproducible transcriptional start sites and their alternative regulation using capped analysis of gene expression (CAGE).
Ohmiya H, Vitezic M, Frith MC, Itoh M, et al.
BMC Genomics. 2014 Apr 25;15(1):269.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.