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KAPA2G Fast Hot Start DNA polymerase, DNA Sequencing 2008 Report, MasterPure RNA purification kit, MultiGrade Gradient Thermal Cycler

Kapa Biosystems has released KAPA2G Fast Hot Start DNA polymerase, a second-generation polymerase engineered for speed, specificity, and performance. The enzyme was engineered using Kapa’s molecular evolution platform. The enzyme can synthesize DNA at a much faster rate than wild-type polymerases, extending DNA at a rate of 1 second per kilobase with no loss in performance, according to the company.

Research and Markets of Dublin has published a new report, entitled "DNA Sequencing 2008." The study focuses on the methods, instruments and software of DNA sequencing in medical research, agriculture and animal husbandry, and DNA testing and forensics application areas. Automated and non-automated DNA sequencing methods are analyzed. The report includes market data, segmentation, market size, key trends, M&A, product developments, industry forecasts, and corporate intelligence and lists 430 companies that are engaged in DNA sequencing services, instrumentation, R&D, and supply of products and services.

Epicentre Biotechnologies has launched a MasterPure RNA purification kit. The kit offers increased yields of total RNA, compared to conventional methods, according to the company. Gentle salt precipitation preserves microRNAs and other small RNAs that would be lost with a spin-column kit. Up to 25 micrograms of RNA can be obtained from 5 milligrams of mouse liver.

MIDSCI has released the MultiGene Gradient Thermal Cycler. The instrument features an easy-to-use interface for setting up protocols, the company claims. Protocols can be optimized by using a 12-row gradient which can be set up across the block. Several common protocols come pre-programmed and can be customized. The 96 x 0.2 milliliter block version is currently available and is compatible with all major brands of tubes, strips, and plates. The 96-well version will be upgradeable to a 60 x 0.5 milliliter block or a 384-well format.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.