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Just Like Times Square

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One of the things I realized I liked when I moved back east to New York after living in the South and out West is the sheer number of people walking around the city at any given time. There's the mad rush in the morning to get on the subway and into crowded restaurants at night. It's a bustling city. There are so many people. Then again, there are so many people.

Academia, too, is bustling: it's full of PhDs and postdocs trying to find a quieter place to call their own, but they are having more trouble than just moving across the river to find a home. In this month's cover story, Tracy Vence looks into how academia came to be so crowded, tracing it back in the biomedical sciences to the doubling of the NIH budget. She says it's a cycle that perpetuates itself: when more faculty are hired, they need more graduate students and postdocs to work in their labs, leaving those researchers to eventually try to find faculty positions — and not all of them can. Many, then, are turning to careers in biotech, and there are now some programs in place to PhDs learn the business side of industry. In addition, Tracy reports that some creative types are looking for ways to slow the growth and find new opportunities for those PhDs who cannot find a spot for themselves in academia.

Elsewhere in this issue, Christie Rizk looks into a burgeoning collaboration among synthetic biology researchers. Jay Keasling, Drew Endy, and others have come together to standardize parts and devices for use in synthetic biology. In addition, Matthew Dublin finds that exome sequencing is carving out a niche for itself in the research world. It may be more than a stopgap, just-wait-until-we-have-whole-genome-sequencing technology, he reports. Indeed, there are a number of large-scale exome sequencing projects in the works in the US and around the world and some researchers are beginning to apply it beyond Mendelian diseases to more complex ones. Finally, in our ethics column, Christie says researchers might want to consider, prior to publishing their work, the possible nefarious uses their research could be put to.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.