Sequencing-based noninvasive prenatal tests that screen for aneuploidies such as Down syndrome and Edwards syndrome are rapidly becoming part of clinical care, especially for women at elevated risk for fetal aneuploidies.

While these tests in general have very high sensitivities and specificities, one factor that physicians and providers of the test are finding to be important for accuracy is the amount of fetal DNA present in the maternal plasma, with false negatives often occurring in samples with low amounts of fetal DNA.

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