Skip to main content
Premium Trial:

Request an Annual Quote

Immune Repertoire Profiling Startup MLC Dx Raises $6M in Private Funding Round


By Julia Karow

MLC Dx has raised almost $6 million in private equity that is part of a $9.7 million financing round, according to a filing with the US Securities and Exchange Commission earlier this month.

The San Francisco-based molecular diagnostics startup was founded in 2008, according to the filing, and is led by president and CEO Thomas Willis. Malek Faham is the company’s CSO (see Paired Ends, this issue).

Faham and Willis have a patent pending that describes methods “for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions,” according to the recently published patent application.

In particular, the application covers a method for profiling recombined T-cell and B-cell receptors using sequencing.

MLC Dx is not the only company exploring the use of sequencing to profile the immune repertoire. Earlier this year, for example, Seattle-based Adaptive TCR Technologies, a spin-off from the Fred Hutchinson Cancer Research Center, started to offer T-cell receptor profiling services (IS 7/20/2010).

In addition, iRepertoire, a recent spin-off from the HudsonAlpha Institute for Biotechnology based in Huntsville, Ala, is offering sequencing-based immune repertoire services for B-cells and T-cells.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.