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Illumina, Epicentre, Integrated DNA Technologies

Illumina has launched two applications that use the company’s Genome Analyzer to generate genome-wide sequencing-based expression profiles of messenger RNA and small RNA. The so-called Digital Gene Expression applications have been in early-access testing since February, the company said.
Digital Gene Expression for Tag Profiling can generate profiles for “any transcript from any gene in any organism,” and offers better sensitivity than serial analysis by gene expression, the company said.
Digital Gene Expression for Small RNA Analysis can analyze up to four million small RNAs simultaneously in one sample.

Epicentre has released the BACMAX DNA Purification Kit, which isolates intact BAC DNA without binding columns, resins, or organic extractions. The BAC DNA is suitable for many applications, including sequencing, fingerprinting, PCR, and preparation of shotgun libraries, the company said. The protocol is based on a modified alkaline-lysis procedure that typically yields 0.6 micrograms to 25 micrograms of BAC DNA from a 1.5 ml to 100 ml culture of a single-copy BAC.

Integrated DNA Technologies has launched the miRCat small RNA cloning system, which allows researchers to create libraries of small RNAs, including miRNAs, piRNAs and endogenous siRNAs, from any primary RNA source. The system is compatible with most standard laboratory protocols for processes such as RNA extraction, purification, and cloning, the company said.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.