Harvard Team Improves Church's Polony Technology to Profile mRNA in Heart Muscle | GenomeWeb
A group of researchers from Harvard Medical School has improved the performance of George Church’s home-built polony sequencing-by-ligation technology and has used it to analyze messenger RNA in murine heart tissues.
The system was significantly cheaper to build than it would have been to buy any of the commercially available next-gen sequencing platforms, though it currently does not match the commercial sequencers in technical performance metrics like read length or throughput.

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