The Great Debate Rages On

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The battle between whole-genome and whole-exome sequencing has been waged for years. Researchers have discussed whether one approach or the other is better for different purposes — basic versus clinical research, complex versus Mendelian diseases, sequencing thousands of genomes versus just a few. Many researchers consider the debate both useful and practical, to help them clarify the uses of each method, how they could be used together, or how to best develop pipelines to analyze the data coming from them.

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