NEW YORK (GenomeWeb) – Genome organization can vary significantly within cells and by allele, according to a team from the National Cancer Institute, Harvard University, the University of Massachusetts, and the Massachusetts Institute of Technology.

"Our findings reveal a remarkably high degree of cell-to-cell and allele-to-allele heterogeneity in spatial genome organization," senior author Tom Misteli, director of NCI's Center for Cancer Research, and his co-authors wrote.