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Genomatix Genome Analyzer, MacVector 10, COSMIC Release 38

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Genomatix Software has released Genomatix Genome Analyzer, an integrated hardware and software solution for the analysis of data generated by next-generation sequencing platforms from Illumina, Roche/454, Applied Biosystems, and Helicos BioSciences. The software helps with the analysis of mammalian ChIP-seq and transcriptome studies. The GGA is driven by an integrated browser-based interface. All database structures, scripts, and tools are open and accessible for re-arrangement or integration of other procedures.
 

 
MacVector has released MacVector 10, a desktop sequence analysis application for Macintosh computers. The new version has a tabbed view of the sequence and a dynamic automatic restriction enzyme display to simplify clone construction. It also has a new feature editor to simplify the creation of GenBank-style annotations, and a redesigned Entrez browser with support for more databases and retrieval of genomic “contig” sequences. Primer design has also been updated, with a new Primer3-based primer design function with support for real-time PCR primers.
 
In addition, the company has released a new version of Assembler, a desktop sequence assembly plugin for MacVector, which now offers real-time translation of contigs.
 

 
COSMIC, the Catalog of Somatic Mutations in Cancer, release 38 is available here. COSMIC v38 contains updates on a number of cancer-related genes.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.