GenBank release 169.0 is now available here via FTP from the National Center for Biotechnology Information. It contains data as of Dec. 11. The new release comprises approximately 99.1 gigabases of data and 98.9 million entries from non-WGS, non-CON sequences; and 141.4 gigabases of data and 48.4 million entries from WGS sequences.
Uncompressed, the 169.0 release flatfiles require about 381 GB for sequence files only. The ASN.1 data require approximately 349 GB.