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New Products: Dec 16, 2008

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GenBank release 169.0 is now available here via FTP from the National Center for Biotechnology Information. It contains data as of Dec. 11. The new release comprises approximately 99.1 gigabases of data and 98.9 million entries from non-WGS, non-CON sequences; and 141.4 gigabases of data and 48.4 million entries from WGS sequences.
 
Uncompressed, the 169.0 release flatfiles require about 381 GB for sequence files only. The ASN.1 data require approximately 349 GB.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.