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Funding Update: Jun 16, 2009

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Sequencing-Related NIH Funding, FY 2009, March 27 — June 15, 2009

The Temporal Reconfiguration of Regulatory Networks: From Yeast to Cancer
Principal Investigator: Aviv Regev
Institution: Massachusetts Institute of Technology
Start date: Sept 30, 2008
End date: July 31, 2013
FY 2009 funding: NA
NIH Institute: Office of the Director


High Throughput DNA Sequencer
Principal Investigator: Suzanne Sandmeyer
Institution: University of California, Irvine
Start date: May 1, 2009
End date: April 30, 2010
FY 2009 funding: $500,000
NIH Institute: National Center for Research Resources


Illumina Genome Analysis System
Principal Investigator: Michael Sussman
Institution: University of Wisconsin Madison
Start date: April 1, 2009
End date: March 31, 2010
FY 2009 funding: $495,000
NIH Institute: National Center for Research Resources


Illumina Genome Analyzer II
Principal Investigator: David Bishop
Institution: Mount Sinai School of Medicine of New York University
Start date: April 1, 2009
End date: March 31, 2010
FY 2009 funding: $338,000
NIH Institute: National Center for Research Resources


Intellectual Property Challenges for the Development of Genomic Diagnostics
Principal Investigator: Subhashini Chandrasekharan
Institution: Duke University
Start date: April 1, 2009
End date: March 31, 2011
FY 2009 funding: $78,000
NIH Institute: National Human Genome Research Institute


Massively Parallel Analysis of Integration in Therapeutic Gene Transfer
Principal Investigator: Frederic Bushman
Institution: University of Pennsylvania
Start date: June 15, 2009
End date: May 31, 2013
FY 2009 funding: NA
NIH Institute: National Institute of Allergy and Infectious Diseases


The Human Virome in Children and its Relationship to Febrile Illness
Principal Investigator: Gregory Storch
Institution: Washington University
Start date: May 8, 2009
End date: April 30, 2010
FY 2009 funding: $954,385
NIH Institute: National Institute of Allergy and Infectious Diseases


Molecular and Informatics Methods for Whole-Genome Mutational Profiling
Principal Investigators: Marc-Jan Gubbels, Gabor Marth
Institution: Boston College
Start date: June 1, 2009
End date: May 31, 2011
FY 2009 funding: NA
NIH Institute: National Institute of Allergy and Infectious Diseases


High Throughput Genome Sequencer for Organ Building
Principal Investigator: Richard Maas
Institution: Brigham and Women's Hospital
Start date: March 27, 2009
End date: Feb 28, 2010
FY 2009 funding: $498,740
NIH Institute: National Center for Research Resources


Somatic Mutation Discovery in Lung Squamous Cell Carcinoma
Principal Investigator: Alexis Ramos
Institution: Harvard University Medical School
Start date: Nov 16, 2008
End date: Nov 15, 2011
FY 2009 funding: NA
NIH Institute: National Cancer Institute

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Technology for Sensitive and Reliable Mutational Profiling in Pancreatic Cancer
Principal Investigator: Mike Makrigiorgos
Institution: Dana-Farber Cancer Institute
Start date: April 1, 2009
End date: March 31, 2012
FY 2009 funding: $227,040
NIH Institute: National Cancer Institute


An Efficient Lightweight Environment for Biomedical Computation
Principal Investigator: Anton Nekrutenko
Institution: Pennsylvania State University-University Park
Start date: May 1, 2009
End date: Feb. 29, 2012
FY 2009 funding: $479,349
NIH Institute: National Human Genome Research Institute


High-Throughput Sequencing Instrument for Stanford Cancer Center
Principal Investigator: Patrick Brown
Institution: Stanford University
Start date: April 19, 2009
End date: April 18, 2010
FY 2009 funding: $500,000
NIH Institute: National Center for Research Resources


Metagenomic Study of the Human Skin Microbiome Associated with Acne
Principal Investigators: Huiying Li, Robert Modlin
Institution: University of California, Los Angeles
Start date: May 15, 2009
End date: April 30, 2010
FY 2009 funding: NA
NIH Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases


A New Methodology to Decipher Three-Dimensional Genome Structure
Principal Investigator: Kenichi Noma
Institution: Wistar Institute
Start date: Sept 30, 2008
End date: Aug 31, 2013
FY 2009 funding: NA
NIH Institute: Office of the Director


Dissection of Two Rheumatoid Arthritis Risk Loci from Genome-Wide Studies
Principal Investigator: Robert Plenge
Institution: Brigham and Women's Hospital
Start date: May 15, 2009
End date: April 30, 2014
FY 2009 funding: NA
NIH Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases


Massively Parallel Sequencing Technology for Cancer Epigenome
Principal Investigator: Lanlan Shen
Institution: University of Texas MD Anderson Cancer Center
Start date: April 1, 2009
End date: March 31, 2011
FY 2009 funding: $169,400
NIH Institute: National Cancer Institute


Massively Parallel Sequencing of the Diapause Transcriptome in Aedes albopictus
Principal Investigators: Peter Armbruster, David Denlinger
Institution: Georgetown University
Start date: June 19, 2009
End date: May 31, 2011
FY 2009 funding: NA
NIH Institute: National Institute of Allergy and Infectious Diseases


Unraveling the Genetic Architecture of Very High HDL cholesterol though Transcrip[tome Resequencing]
Principal Investigator: Michael Miller
Institution: University of Maryland Baltimore
Start date: May 1, 2009
End date: April 30, 2011
FY 2009 funding: $157,500
NIH Institute: National Heart, Lung, and Blood Institute


Algorithmic Strategies for Detecting Structural Variation in Genomes
Principal Investigator: Vineet Bafna
Institution: University of California, San Diego
Start date: April 1, 2009
End date: Feb 28, 2013
FY 2009 funding: $330,660
NIH Institute: National Human Genome Research Institute

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High-throughput Genetic Analyzer Upgrade for Comparative Population Genomics
Principal Investigator: Adalgisa Caccone
Institution: Yale University
Start date: May 1, 2009
End date: April 30, 2010
FY 2009 funding: $92,429
NIH Institute: National Center for Research Resources


E. coli Quiescent Systems for Mammalian Expression of Unclonable DNA
Principal Investigator: Ronald Godiska
Institution: Lucigen, Middleton, Wis.
Start date: July 10, 2008
End date: Dec 31, 2009
FY 2009 funding: N/A
NIH Institute: National Human Genome Research Institute


Analyzing Allele Specific Gene Expression and Regulation in C. Albicans.
Principal Investigator: Sadie Marjani
Institution: Yale University
Start date: Oct 20, 2009
End date: N/A
FY 2009 funding: $50,054
NIH Institute: National Institute of General Medical Sciences


Massively Parallel Single Cell Genomics of the Human Microbiome
Principal Investigator: David Mead
Institution: Lucigen, Middleton, Wis.
Start date: Sept 1, 2008
End date: Feb 28, 2010
FY 2009 funding: N/A
NIH Institute: National Institute of Allergy and Infectious Diseases


Genomics/Bioinformatics Core
Principal Investigator: Stanley Nelson
Institution: University of California Los Angeles
Start date: N/A
End date: N/A
FY 2009 funding: N/A
NIH Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases


Evaluation of the Cutaneous Microbiome in Psoriasis
Principal Investigator: Martin Blaser
Institution: New York University School of Medicine
Start date: May 7, 2009
End date: April 30, 2010
FY 2009 funding: N/A
NIH Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases


High Throughput Microrepository for Genetic Materials
Principal Investigator: Robert Haushalter
Institution: Parallel Synthesis Technologies, Santa Clara, Calif.
Start date: Sept. 1, 2008
End date: Feb. 28, 2010
FY 2009 funding: N/A
NIH Institute: National Human Genome Research Institute


New Light Technology for Inducing Fluorescence for Bioanalysis
Principal Investigator: Claudia Jaffe
Institution: Lumencor, Beaverton, Ore.
Start date: Aug. 1, 2008
End date: Jan. 31, 2010
FY 2009 funding: N/A
NIH Institute: National Institute of General Medical Sciences


Rise of HIV-1 Low-Level Viremia as an Early Predictor of Virologic Rebound
Principal Investigator: John McKinnon
Institution: University of Pittsburgh at Pittsburgh
Start date: June 5, 2009
End date: May 31, 2011
FY 2009 funding: N/A
NIH Institute: National Institute of Allergy and Infectious Diseases


Application of 454 Sequencing to Cancer Epigenomics
Principal Investigator: Huidong Shi
Institution: Medical College of Georgia
Start date: May 1, 2009
End date: April 30, 2012
FY 2009 funding: $321,334
NIH Institute: National Cancer Institute

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Computer Cluster and Storage to Support Whole Genome Sequencing and Analysis
Principal Investigator: Eric Sobel
Institution: University of California, Los Angeles
Start date: May 14, 2009
End date: May 13, 2010
FY 2009 funding: N/A
NIH Institute: National Center for Research Resources


Construction of a Reference Sequence Data Set for The Human Microbiome Project
Principal Investigator: Robert Strausberg
Institution: J. Craig Venter Institute
Start date: May 22, 2009
End date: April 30, 2011
FY 2009 funding: N/A
NIH Institute: National Institute of Allergy and Infectious Diseases


Sequencing the Human Microbiome
Principal Investigator: George Weinstock
Institution: Washington University
Start date: My 22, 2009
End date: April 30, 2013
FY 2009 funding: N/A
NIH Institute: National Human Genome Research Institute


High-performance Computing System for Bioinformatics
Principal Investigator: Huntington Willard
Institution: Duke University
Start date: June 1, 2009
End date: May 31, 2010
FY 2009 funding: N/A
NIH Institute: National Center for Research Resources

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.