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Funding Update: Apr 28, 2009


Software and Server for Taxonomic Binning of Metagenomic Sequences

Start Date: April 15, 2009
Expires: March 31, 2010
Awarded Amount to Date: $315,723
Principal Investigator: Andrey Tovchigrechko
Sponsor: J. Craig Venter Institute

Supports the development of MGTAXA, a freely available software and a web server for taxonomic classification of metagenomic sequences with machine learning techniques. The project will build three major components: a toolbox for reliable assignment of species composition to large collections of unassembled environmental sequencing data, with automated and regular updates of databases and models; a public web server with a high-performance computational back end that will let a wide community of biologists build classification models specific to their metagenomic samples; and an online instructional environment where students and educators can combine several machine learning algorithms into graphically represented pipelines, apply them to sequences from annotated genomes, and contribute to the reusable repository of exercises and small research projects.

Complete Genome Sequencing of Four Nitrogen-fixing, Plant-associated Burkholderias

Start Date: Sept. 1, 2008
Expires: Sept. 30, 2009
Awarded Amount to Date: $304,444
Principal Investigator: George Weinstock
Sponsor: Washington University School of Medicine

The project will produce genome sequences for four plant-associated Burkholderia species: B. sp. PVA5, B. tuberum STM-678T, B. unamae MtI-641T, and B. sp. SRMrh-20. Pyrosequencing will be used to analyze the 7 million base pairs of each of these genomes. From these data, researchers will compile a complete description of the genes contained in each bacterium, analyze them for physiological mechanisms for nitrogen fixation, and compare them to other nitrogen-fixing bacteria, particularly the phylogenetically distinct rhizobia.

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.