'Footprint' Approach Maps Regulatory Protein Binding | GenomeWeb

NEW YORK (GenomeWeb News) – A team of researchers from the University of Washington has developed a technique for mapping regulatory protein occupancy across the genome, without prior knowledge of the specific proteins involved.

The approach, which they dubbed "digital genomic footprinting" relies on a combination of DNase I cleavage and high throughput, massively parallel sequencing. The team applied their genomic footprinting to the model organism Saccharomyces cerevisiae, or baker's yeast, identifying thousands of proposed protein binding regions in the genome.

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