NEW YORK (GenomeWeb News) – Elevated schizophrenia risk appears to stem from a preponderance of deleterious de novo mutations, including recurrent mutations to a handful of potential risk genes, according to an exome sequencing study appearing online today in Nature Genetics.

Columbia University researchers did exome sequencing on nearly 800 individuals with or without schizophrenia, including more than 200 South African and American trios comprised of affected individuals and their parents.

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