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New Products: Dec 9, 2008

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The Sept. 2007 EquCab2 release of the horse genome is now available in the University of California, Santa Cruz, Genome Browser. The assembly was produced by the Broad Institute.
 
The horse draft genome has been sequenced to 6.8X coverage. Approximately 84 percent of the sequence has been anchored to chromosomes, which include autosomes 1-31 and sex chromosome X, UCSC said. Unanchored contigs that could not be localized to a chromosome have been concatenated into the virtual chromosome "chrUn," separated by gaps of 1,000 bp. The mitochondrial sequence is also available in the Genome Browser as the virtual chromosome "chrM."
 
More details about the current assembly are available on the Broad Institute’s Horse Genome Project website here. Bulk downloads of the sequence and annotation data are available from the Genome Browser FTP server and downloads page.  

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.