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Epicentre Biotechnologies, SoftGenetics, Ensembl 43, PAMGO

Epicentre Biotechnologies has released BACMAX96, a DNA purification kit that can purify 384 fosmids or BACs in less than four hours in a 96-well-format. According to the company, the BACMAX96 kit consistently yields up to 900 nanograms of DNA from single-copy BAC and fosmid clones, and from 2.5 micrograms to 6 micrograms of DNA from the company’s CopyControl BAC and fosmid clones induced to high copy number. The company said it uses an autoinduction protocol specifically designed for high-throughput formats to improve yields from the CopyControl clones.

SoftGeneticsGeneMarker fragment analysis software now includes a new application for loss of heterozygosity analysis. GeneMarker directly processes electrophoretic separation data, performs sizing calculations, normalizes the data, detects areas of LOH, and provides researchers and clinicians with a patient report, the company said.

Ensembl 43 is available here. The release includes genome sequence data for four new species: cat, tree shrew, hedgehog, and guinea pig; a new cow assembly and genebuild; updates for the human and mouse databases; and new variation data for human, rat, and mouse.

The PAMGO consortium has released 472 new terms to describe gene products involved in microbial-host interactions. The new PAMGO terms are available under “multi-organism processes” in the AmiGO Gene Ontology browser. PAMGO was formed to develop new GO terms that describe processes, functions, and cellular components related to microbe-host interactions. Further information about the PAMGO effort is available here.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.