EM-based Dissection Method Enables Sequencing of Individual Nuclear Bodies from Single Cells | GenomeWeb

NEW YORK (GenomeWeb) − Researchers in Toronto have developed a method to dissect and sequence DNA from structures within the nucleus of individual cells, allowing them to study the spatial arrangement of genes in great detail.

Chromosomal DNA is not randomly distributed in the nucleus − the position of genes is highly organized. Certain gene loci come together in sub-nuclear structures, called nuclear bodies, which contain proteins and regulate their expression.

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