DNA Degradation Features Help Team Map Nucleosomes, Methylation in Ancient Genome Sequences | GenomeWeb

By exploiting sequence and read depth signals that reflect degradation, damage, and protection in ancient DNA, a Danish-led team has come up with treatment-free methods for profiling genome-wide methylation and nucleosome packaging patterns in ancient genomes.

The approaches rely on read depth and deamination profiles to reveal nucleosome occupancy and cytosine methylation, respectively, rather than sequencing DNA treated with nucleases or bisulfite.

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