Skip to main content
Premium Trial:

Request an Annual Quote

Decode and Pfizer to Analyze Lupus Patient Genomes for Disease-Associated Variants

Premium

Decode Genetics and Pfizer are collaborating to discover sequence variants associated with clinical phenotypes of systemic lupus erythematosis, Decode said this week.

Over the next 18 months, the partners will jointly analyze the genomes of an undisclosed number of lupus patients, with the aim to find sequence variants that could help them understand existing drug targets and identify novel targets. Another goal is to develop tools for patient stratification and companion diagnostics.

The collaboration will make use of Decode's population genetics resources and analytical expertise, including next-gen sequencing, and Pfizer's ability to apply genomic analyses to drug discovery and development.

According to its website, Decode has collected genotypic and medical data from more than 140,000 volunteers in Iceland, or more than half the island's adult population.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.