COSMIC, the Catalog of Somatic Mutations in Cancer, release 39 is available here. For version 39, the database and web interfaces have been upgraded to handle next-generation sequencing data as part of ongoing work to allow COSMIC to handle the increased volumes and complexity of somatic data that these technologies are expected to yield. In particular, COSMIC has been adapted to handle large-scale structural variants, including translocations, large insertions/deletions, inversions, and duplications.