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COSMIC 39

Oct 21, 2008
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COSMIC, the Catalog of Somatic Mutations in Cancer, release 39 is available here. For version 39, the database and web interfaces have been upgraded to handle next-generation sequencing data as part of ongoing work to allow COSMIC to handle the increased volumes and complexity of somatic data that these technologies are expected to yield. In particular, COSMIC has been adapted to handle large-scale structural variants, including translocations, large insertions/deletions, inversions, and duplications.

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Clinical Sequencing
Sequencing
Breaking News
The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.