Investment firm William Blair and Company began covering Pacific Biosciences this week with a "Market Perform" rating, but estimated that sales of the company's RS machine will be slightly below consensus estimates.

The firm predicted PacBio will ship 46 instruments in 2011, 125 in 2012, and 170 in 2013, which is 99 fewer total instruments than the 440 machines analysts previously predicted PacBio will ship by 2013.

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