NEW YORK (GenomeWeb) – Extrachromosomal circular DNA (eccDNA) elements are common in healthy human tissue, and some are even large enough to house one or more complete genes that could be expressed, a new analysis has found.

While the human genome is typically organized into stable chromosomes, tumor cells have been known to accumulate eccDNA. But researchers led by the University of Copenhagen's Birgitte Regenberg suspected that such circular DNA might also accumulate in normal cells, especially as deleted and damaged DNA are marked for destruction.

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