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Cancer Sequencing Papers of Note: Apr 19, 2011


MicroRNA expression signatures of bladder cancer revealed by deep sequencing.
Han Y, Chen J, Zhao X, et al.
PLoS One. 2011 Mar 28;6(3):e18286.

Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.
Hillmer AM, Yao F, Inaki K, et al.
Genome Res. 2011 Apr 5. [Epub ahead of print]

Transcriptional consequences of genomic structural aberrations in breast cancer.
Inaki K, Hillmer AM, Ukil L, et al.
Genome Res. 2011 Apr 5. [Epub ahead of print]

Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing.
Fu Y, Sun Y, Li Y, et al.
Genome Res. 2011 Apr 7. [Epub ahead of print]

Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.
Brognard J, Zhang YW, Puto LA, Hunter T.
Cancer Res. 2011 Apr 12. [Epub ahead of print]

Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy.
Sinclair PB, Parker H, An Q, et al.
Hum Mol Genet. 2011 Apr 12. [Epub ahead of print]

Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma.
Valsesia A, Rimoldi D, Martinet D, et al.
PLoS One. 2011 Apr 8;6(4):e18369.

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias.
Itzykson R, Kosmider O, Cluzeau T, et al.
Leukemia. 2011 Apr 15. [Epub ahead of print]

Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual.
Galante PA, Parmigiani RB, Zhao Q, et al.
Nucleic Acids Res. 2011 Apr 14. [Epub ahead of print]

High-resolution characterization of a hepatocellular carcinoma genome.
Totoki Y, Tatsuno K, Yamamoto S, et al.
Nat Genet. 2011 Apr 17. [Epub ahead of print]

Exome sequencing identifies GRIN2A as frequently mutated in melanoma.
Wei X, Walia V, Lin JC, et al.
Nat Genet. 2011 Apr 15. [Epub ahead of print]

PathScan: A tool for discerning mutational significance in groups of putative cancer genes.
Wendl MC, Wallis JW, Lin L, et al.
Bioinformatics. 2011 Apr 14. [Epub ahead of print]

Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma.
Arron ST, Ruby JG, Dybbro E, Ganem D, Derisi JL.
J Invest Dermatol. 2011 Apr 14. [Epub ahead of print]

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge is weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.