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Cancer Sequencing Papers of Note: Apr 5, 2011


Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
Wartman LD, Larson DE, Xiang Z, et al.
J Clin Invest. 2011 Mar 23. pii: 45284. [Epub ahead of print]

Initial genome sequencing and analysis of multiple myeloma.
Chapman MA, Lawrence MS, Keats JJ, et al.
Nature 2011. Mar 24;471(7339):467-72.

Assessing matched normal and tumor pairs in next-generation sequencing studies.
Goh L, Chen GB, Cutcutache I, et al.
PLoS One. 2011 Mar 18;6(3):e17810.

Analysis of mitochondrial ND1 gene in human colorectal cancer.
Akouchekian M, Houshmand M, Akbari MH, et al.
J Res Med Sci. 2011 Jan;16(1):50-5.

Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries.
Corbo V, Beghelli S, Bersani S, et al.
Ann Oncol. 2011 Mar 29. [Epub ahead of print]

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.