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Cancer Sequencing Papers of Note: Mar 16, 2011


Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
Yan XJ, Xu J, Gu ZH, et al.
Nat Genet. 2011 Mar 13. [Epub ahead of print]

Tumor evolution inferred by single-cell sequencing.
Navin N, Kendall J, Troge J, et al.
Nature. 2011 Mar 13. [Epub ahead of print]

IgH gene rearrangements as plasma biomarkers in non-Hodgkin's lymphoma patients.
He J, Wu J, Jiao Y, et al.
Oncotarget. 2011 Mar 8;2(3). [Epub ahead of print]

Functional synergies yet distinct modulators affected by genetic alterations in common human cancers.
Bessarabova M, Pustovalova O, Shi W, et al.
Cancer Res. 2011 Mar 11. [Epub ahead of print]

CREBBP mutations in relapsed acute lymphoblastic leukemia.
Mullighan CG, Zhang J, Kasper LH, et al.
Nature. 2011 Mar 10;471(7337):235-9.

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.
Wagle N, Emery C, Berger MF, et al.
J Clin Oncol. 2011 Mar 7. [Epub ahead of print]

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.