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CAMERA 1.2.6, PCRboost

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Version 1.2.6 of CAMERA is available here. The new version includes six new publicly available metagenomic datasets, including the Mediterranean gutless worm metagenome, the acid mine drainage metagenome, and the Waseca county farm soil metagenome. The database also includes a new annotation pipeline, improved navigation, improved Blast services, and an enhanced fragment recruitment viewer.
 

 
Biomatrica has introduced PCRboost, a reagent that enhances PCR and RT-PCR amplification of difficult samples. Researchers replace the water in the reaction with PCRboost to improve amplification of trace samples of less than or equal to 1 nanogram, degraded samples, low-copy transcripts, multiplexing, and samples containing inhibitory factors.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.