Researchers from the Broad Institute are designing a microfluidics-based low-cost sample preparation protocol for next-generation sequencing and have built a prototype chip that consists of around 100 40-nanoliter circular reactors in which all the steps of library construction can be performed.

Paul Blainey, a core member of the Broad Institute and assistant professor of biological engineering at MIT, presented on the technique at last month's Advances in Genome Biology and Technology meeting in Marco Island, Fla.

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