For every mutant KRAS gene circulating in plasma, there are as many as 10,000 wild-type copies. At the annual Advances in Genome Biology and Technology meeting held in Marco Island, Fla., in February, Boreal Genomics' Andre Marziali described how his company's OnTarget platform can selectively deplete wild-type alleles and enrich their mutant counterparts, even those that differ by a single base. The allele-enrichment system will enable researchers and clinicians to detect cancer-related mutations directly in plasma, he said at the time.

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In Science this week: mtDNA analysis give glimpse into decline of Neanderthals in Europe, and more.

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