NEW YORK (GenomeWeb) – Researchers from Brazil, the US, and elsewhere used tissue transcriptome sequences to assemble a de novo genome for the jaguar, Panthera onca, to help elucidate the big cat's gene set and search for clues to its biology.

But the team did not stop there. It also assembled a new leopard genome sequence and sequenced dozens of jaguar exomes in an effort to understand adaptations and relationships across the Panthera genus, which includes lions, tigers, leopards, snow leopards, and jaguars.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

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