NEW YORK (GenomeWeb News) — Both of the currently marketed next-gen sequencers — 454’s GS 20 and Solexa’s 1G Genome Analyzer — use sequencing-by-synthesis to read the DNA. But sequencing technologies based on new variations on this theme are starting to crop up.
 
One developer of such a technology is Mike Metzker, whose research group at Baylor College of Medicine’s Human Genome Sequencing Center has been developing a reversible terminator chemistry for SBS sequencing and is currently demonstrating its ability to read DNA.

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