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Base4 Raises £5M in Private Financing

NEW YORK (GenomeWeb) – British biotech firm Base4 Innovation announced today that it has raised £5 million ($6.6 million) through an oversubscribed round of private financing.

The round was led by Longwall Ventures. Base4, which has raised £21.3 million since 2009, said it will use the proceeds to expand its team and lab space, as well as the continued development and automation of its single-molecule DNA sequencing technology.

The technology involves using pyrophosphorolysis to release nucleotides from single DNA molecules. Individual nucleotides are then captured into microdroplets that are made to produce their own characteristic fluorescent signal. It has been under development since at least 2014.

The Scan

Looking for Omicron

NPR reports that SARS-CoV-2 testing in the US has gotten better but also that some experts say more needs to be done to better track the Omicron variant.

Holmes Alleges Abuse

The Associated Press reports that Theranos' Elizabeth Holmes has testified at her wire fraud trial that her business and romantic partner abused her.

Bit More Diverse, But More to Do

While Black and Hispanic patients are more likely to participate in cancer clinical trials than previously, they are still underrepresented, according to US News & World Report.

PNAS Papers on Yeast Gene Silencing, Zika Virus Inhibition, Immunoglobulin Hypermutation

In PNAS this week: gene silencing in Saccharomyces cerevisiae, possible neuroprotective role for SHFL in a mouse model of Zika virus infection, and more.